Resembling a cross between a thistle and a dandelion, wild lettuce has been used as a sedative and painkiller for millennia. In the past, some Indian tribes smoked the plant to induce a mild euphoric dream state. Even today, in France, water distilled from wild lettuce is used as a mild sedative.
It has been found that the milky substance given out by wild lettuce contains Lactucopicrin, lactucic acid, sesquiterpene lactone and lactucin, which have been found to have analgesic activity equal or higher to that of Ibuprofen in mice. Moreover, these active ingredients were also found to have sedative activity.